block of 5-ht2 receptors enhances hippocampal long-term potentiation
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abstract
the effect of endogenous serotonin on long-term potentiation (ltp) in region cai was studied by blocking 5-ht2 receptors with ketanserin in rat hippocampal slices. such a block significantly en-hanced long-term potentiation of the cai population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. this implies that serotonin acts on 5-ht2 receptors in cai to repress long-term potentiation.
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Journal title:
iranian biomedical journalجلد ۲، شماره ۳، صفحات ۱۲۹-۱۳۱
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